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The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19.

Di Maro, Martina; Cataldi, Mauro; Santillo, Mariarosaria; Chiurazzi, Martina; Damiano, Simona; De Conno, Barbara; Colantuoni, Antonio; Guida, Bruna.

Front Physiol ; 12: 653985, 2021.

Article in English | MEDLINE | ID: covidwho-1526787

ABSTRACT

The renin angiotensin system and the cholinergic anti-inflammatory pathway have been recently shown to modulate lung inflammation in patients with COVID-19. We will show how studies performed on this disease are starting to provide evidence that these two anti-inflammatory systems may functionally interact with each other, a mechanism that could have a more general physiological relevance than only COVID-19 infection.

NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments.

Damiano, Simona; Sozio, Concetta; La Rosa, Giuliana; Santillo, Mariarosaria.

Front Cell Infect Microbiol ; 10: 608435, 2020.

Article in English | MEDLINE | ID: covidwho-1004674

Subject(s)

COVID-19/metabolism , NADPH Oxidases/physiology , Oxidative Stress , SARS-CoV-2 , Signal Transduction/physiology , Angiotensin-Converting Enzyme 2/metabolism , COVID-19/epidemiology , Cardiovascular Diseases/enzymology , Cardiovascular Diseases/epidemiology , Comorbidity , Diabetes Mellitus, Type 2/enzymology , Diabetes Mellitus, Type 2/epidemiology , Enzyme Activation , Enzyme Inhibitors/pharmacology , Enzyme Inhibitors/therapeutic use , Humans , Metformin/pharmacology , Metformin/therapeutic use , NADPH Oxidase 2/physiology , Obesity/enzymology , Obesity/epidemiology , Oxidation-Reduction , Proto-Oncogene Mas , Proto-Oncogene Proteins/metabolism , Reactive Oxygen Species/metabolism , Receptors, G-Protein-Coupled/metabolism , Receptors, Virus/metabolism , Renin-Angiotensin System , SARS-CoV-2/physiology , COVID-19 Drug Treatment

ABSTRACT

Subject(s)

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